Sequential Astrocytic 5-HT2B Receptor Stimulation, [Ca2+]i Regulation, Glycogenolysis, Glutamate Synthesis, and K+ Homeostasis are Similar but Not Identical in Learning and Mood Regulation

نویسندگان

  • Ye Chen
  • Ting Du
  • Liang Peng
  • Marie E. Gibbs
  • Leif Hertz
چکیده

Citation: Chen Y, Du T, Peng L, Gibbs ME and Hertz L (2016) Sequential Astrocytic 5-HT2B Receptor Stimulation, [Ca ]i Regulation, Glycogenolysis, Glutamate Synthesis, and K Homeostasis are Similar but Not Identical in Learning and Mood Regulation. Front. Integr. Neurosci. 9:67. doi: 10.3389/fnint.2015.00067 Sequential Astrocytic 5-HT2B Receptor Stimulation, [Ca]i Regulation, Glycogenolysis, Glutamate Synthesis, and K Homeostasis are Similar but Not Identical in Learning and Mood Regulation

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Role of glycogenolysis in stimulation of ATP release from cultured mouse astrocytes by transmitters and high K+ concentrations

This study investigates the role of glycogenolysis in stimulated release of ATP as a transmitter from astrocytes. Within the last 20 years our understanding of brain glycogenolysis has changed from it being a relatively uninteresting process to being a driving force for essential brain functions like production of transmitter glutamate and homoeostasis of potassium ions (K+) after their release...

متن کامل

Role of Glycogenolysis in Memory and Learning: Regulation by Noradrenaline, Serotonin and ATP

This paper reviews the role played by glycogen breakdown (glycogenolysis) and glycogen re-synthesis in memory processing in two different chick brain regions, (1) the hippocampus and (2) the avian equivalent of the mammalian cortex, the intermediate medial mesopallium (IMM). Memory processing is regulated by the neuromodulators noradrenaline and serotonin soon after training glycogen breakdown ...

متن کامل

The effect of glutaminergic system on cardiovascular regulation of rat

Introduction: The bed nucleus stria terminalis (BST) is a part of the limbic system, which plays a role in regulation of heart beat and blood circulation. It was recently shown that microinjection of L-glutamate in the BST elicits cardiovascular depressive, but the role of glutamate receptor subtypes has not been investigated yet. In this study, the role of glutamate receptor subgroups in regul...

متن کامل

Signal Transduction in Astrocytes during Chronic or Acute Treatment with Drugs (SSRIs, Antibipolar Drugs, GABA-ergic Drugs, and Benzodiazepines) Ameliorating Mood Disorders

Chronic treatment with fluoxetine or other so-called serotonin-specific reuptake inhibitor antidepressants (SSRIs) or with a lithium salt "lithium", carbamazepine, or valproic acid, the three classical antibipolar drugs, exerts a multitude of effects on astrocytes, which in turn modulate astrocyte-neuronal interactions and brain function. In the case of the SSRIs, they are to a large extent due...

متن کامل

Decrease of gene expression of astrocytic 5-HT2B receptors parallels development of depressive phenotype in a mouse model of Parkinson’s disease

Astrocytes contribute to pathogenesis of neuropsychiatric disorders, including major depression. Stimulation of astroglial 5-HT2B receptors transactivates epidermal growth factor receptors (EGFRs) and regulates gene expression. Previously we reported that expression of 5-HT2B receptors in cortical astrocytes is down-regulated in animals, which developed anhedonia in response to chronic stress; ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 9  شماره 

صفحات  -

تاریخ انتشار 2015